Research Study Degenerative Disc


Sciatica pain holding you back?

If you struggle with back pain and radiating leg pain, tingling, numbness, or muscle weakness, you may qualify for the CLEAR Clinical Study. The study is for an investigational, non-opioid injection designed to relieve sciatica-related back and leg pain. Participants will receive all study-related care at no cost.

80% of Americans are affected by back pain at some point in their lives

Do you struggle with sciatica pain?

Do you have leg pain, tingling, numbness, or muscle weakness that begins in the lower back and seems to travel down the back of one or both legs?

If these symptoms are affecting your quality of life, you may be a candidate for the CLEAR Clinical Research Study.

About sciatica

Sciatica is a relatively common condition as we age. Between 13% and 40% of people will experience symptoms at some point in their lives. It can happen as a result of general wear and tear or due an injury to the disks that cushion the bones (vertebrae) of your lower spine.

If the symptoms of sciatica are affecting your quality of life you may be a candidate for the CLEAR Clinical Research Study. The Study is evaluating an investigational drug for the treatment of sciatica. Eligible participants may be given SP-102 by injection in the lower back.

Do I qualify? How do I learn more about the Study?

The CLEAR Clinical Research Study is currently being conducted at treatment sites throughout the U.S. If you have been diagnosed with, or have the symptoms of sciatica, you can learn more about the CLEAR Clinical Research Study at

To learn more and enroll, please contact:

Pinnacle Pain and Spine

Be part of the future of research in chronic low back pain

If you are an adult with degenerative changes of a disc, you may be eligible to take part in a clinical research study.

The CASCADE Study is looking at the impact of an investigational product for people experiencing chronic low back pain associated with degenerative changes of a disc. The investigational product aims to potentially reduce pain and improve disability that results from the condition. You may be eligible to participate in this study, if you:

    • are 18 years of age or older
    • have a diagnosis of chronic low back pain associated with degenerative changes of a disc
    • have had chronic low back pain for at least 6 months
    • are still experiencing low back pain, despite trying other treatment for at least 6 months.

If you decide to take part in the CASCADE Study, your participation will last approximately 3 years. You will be required to attend the study center a number of times so that the study doctor can assess your condition and overall health. After the start of the study when you receive the investigational product, you will be required to visit after 1, 3, 6, 12, 18, 24, and 36 months.

The study is closed, but it was an honor to be selected to participate in such a wonderful study and the research will continue for years based on information gathered, in part, from Pinnacle Pain and Spine.

– Matthew Crooks, MD

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Overall Rating / 37 Total 1st-Party Reviews

5.0 Out of
5 Stars

Pinnacle Pain and Spine

5.0 out of 5 stars
- June 21, 2018

Excellent!!! During my first visit with Dr. Crooks he had already reviewed my MRI, previous doctor notes, and images. I felt very welcomed with Dr. Crooks and Ramona his nurse! They are both very knowledgeable and caring! My pain is in my cervical area, Dr. Crooks and I disgusted my treatment plan and he thoroughly explained everything to me. I just moved to Arizona from Florida and he has been an excellent Physician! I received a few injections, due to being terribly in pain on my first office visit. I was able to schedule my procedure 2 days later. I was so thankful to have it scheduled! He is truly an amazing Doctor! I would definitely recommend Dr. Crooks! I felt he treated his patients as if they were his own family. He actually took the time to discuss what concerns you have, and what he recommended, and could help with. I am a patient at the Scottsdale office and the staff was very helpful as well. I can not say enough good things about Dr. Crooks! Ramona also was a very sweet, caring, and a magnificent Nurse. She took her time with you as well and I never felt rushed or as if they were to busy to take on a new patient. Definitely an outstanding and wonderful Doctor!


5.0 out of 5 stars
- April 29, 2018

Matthew "Dr. Miracle-worker" Crooks was my latest attempt since 2002 of four other "back specialists". Matthew having studied my previous MRIs decided that RFA was the most likely treatment for success while being the least invasive. He setup an aggressive schedule and only 3 days ago I had my first Lumbar right side RFA. His staff have the process down to a very quick 15-30 minute procedure (although with sedation I remember nothing from when Matthew came in the room until just before my wife drove me home). In total honesty the very next morning is the first time in ten years that I have had NO pain at all, easily stood up straight and wasn't grasping for every wall or counter top as had become normal when attempting to walk. Having not used sedation for the test procedures I know that the scheduling, preparatory, procedure and followup staff were very polite and fun yet super professional at their jobs. After 3 days I am feeling random Lumbar area pain in specific locations, duration, and intensity as the nerves fight their eventual desensitizing of 12-18 pain free months! Danielle, Juliet, Romona, Jay, Kathy, Danny, and Dr. Miracle Worker (and anyone I missed) - MANY THANKS!!


5.0 out of 5 stars
- April 6, 2018

Hello Matthew, We are vetting stem cell therapy providers for a new online directory,, to showcase the best clinics and greatest success stories in each city. You are invited to apply by going to The first two providers accepted in Arizona will receive a COMPLIMENTARY six month premium listing on our directory (Value $3582). I look forward to your application! I will be following up via phone if you have any questions. If you have any questions, please feel free to email me at Thank you! Charissa Just go to to apply.


5.0 out of 5 stars
- March 16, 2018

I can not say enough good things about Dr Crooks and the Pinnacle Pain Staff/Team. I had back pain for nearly 3 years and Dr. Crooks has given me the ability to a full night sleep after my procedure. I was hesitant at first as I fear injections but the staff and Dr Crooks do such a great job at making me feel better. I greatly appreciate his time and consideration, he is a very caring person and a GREAT physician. I highly recommend PPSC- Thank you Dr Crooks!!!!


5.0 out of 5 stars
- January 26, 2018

I came to Dr Crooks with a number of issues which prevented me from living a full and enjoyable life. In a few months Dr Crooks has me back on the golf course, bending over to wash my face and able to lift my leg enough to pull slacks on. I had almost given up thinking I’d ever be able to perform any of these simple tasks and can’t put into words how happy I am every day. Thanks Dr Crooks.


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